TP53 and hepatocellular carcinoma: Here, we first demonstrated that PPa extract inhibited HCC cell proliferation, which was shown in the following cells: HepG2 cells—a cell line with WT p53 derived from a patient from the United States [25]; Mahlavu cells—a cell line with mutated p53 with poor differentiation derived from a patient from Africa; Huh7 cells—a cell line with mutated p53 derived from a Japanese patient [26]; and J5 cells—a cell line derived from Taiwan patients.