Gao et al. recently reported a novel FAK–Wnt regulation axis: FAK and PYK2 were found to be elevated in adenomas in APCmin/+ mice and in human CRC tissues, in addition they promoted Wnt/β-catenin pathway activation by phosphorylating GSK3β leading to β-catenin accumulation, which in turn initiates and supports intestinal tumorigenesis. This evidence concerns the gene PTK2B and colorectal carcinoma.