Genetic alterations in Wnt signaling occur in over 90% of human sporadic CRC, among which inactivation of the tumor suppressor adenomatous polyposis coli (APC) occur in 85% of the cases, while activating mutations of the proto-oncogene β-catenin (CTNNB1) occur only in 5% of the cases [66]. The gene discussed is APC; the disease is colorectal carcinoma.