PTK2 and breast carcinoma: In another study, beta 1 integrin (ITGB1) was identified as a key mediator for Twist-induced EMT, where Twist was shown to induce EMT and cell motility in breast cancer, by regulating a complex signaling network consisting of ITGB1-FAK/ILK axis, PI3K/AKT, MAPK/ERK, Wnt, and P53 signaling [98].