It was earlier published that synthetic analogues of the asterriquinones, 1H5 and 5E5, have activated TrkA tropomyosin receptor kinase A directly in the cells and protected differentiated PC12 cells (rat adrenal pheochromocytomas) or contributed to the differentiation of neurons [62,63]. This evidence concerns the gene NTRK1 and adrenal gland pheochromocytoma.