INSR and obesity due to melanocortin 4 receptor deficiency: Likewise, it will be relevant to identify the role of paralogs and/or alternatively spliced mTOR intrinsic regulatory components in its two major cellular complexes—mTORC1 (Raptor-driven) and mTORC2 (Rictor-driven) [44]—towards affecting the IR/IGF1R signaling in obesity/diabetes and cancer.