Downregulation of PRDX3 has been detected in the presence of mutant SOD1G93A motor neuronal-like NSC34 cells, in the spinal cord mitochondria of mutant SOD1 transgenic mice, but also in spinal motor neurons from patients with both sporadic and SOD1-related motor neuron disease (MND). Here, SOD1 is linked to mild neurocognitive disorder.