CXCL8 and necrotizing vasculitis: In addition, inflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1β, and IL-8/CXCL8 are produced in response to antigen stimulation, and vascular endothelial cell damage due to degranulation and immune complex deposition associated with neutrophil activation leads to necrotizing vasculitis [10,11].