CPQ and plasma cell myeloma: Melphalan flufenamide (melflufen) is a novel lipophilic peptide-conjugated alkylator that is rapidly taken up by myeloma cells due to its high lipophilicity and through aminopeptidases action is cleaved into melphalan and p-Fluorophenylalanine, that leads to melphalan accumulation and consequently DNA damage and apoptosis [84].