Naringenin inhibits proliferation and induces apoptosis of A549 cells by inducing death receptor 5 (DR5) expression in human lung cancer cells and Naringin also be able to inhibit Akt activity and down-regulates MMP-2 and MMP-9 to inhibit migration of A549 cells [35,36]. This evidence concerns the gene TNFRSF10B and lung cancer.