TBK1 and amyotrophic lateral sclerosis: Finally, expression of TBK1 was reduced in patient-derived lymphoblastoid cells carrying an ALS-associated chr12:65059913G>A mutation within a TBK1 enhancer compared to mean expression in cells derived from neurologically normal controls, although this difference was not statistically significant (24% reduction; p = 0.27; Welch’s t test; Figure S2).