CAV1 and amyotrophic lateral sclerosis: The association of CAV1 function with neurotrophic signaling is consistent with this premise; identified deficient neurotrophic signaling in ALS has been proposed as a risk factor that increases the vulnerability of motor neurons to additional insults (Bemelmans et al., 2006; Ghavami et al., 2014; Kowiański et al., 2018; Tooze and Schiavo, 2008).