ALS is defined by motor neuron death within the CNS; in motor neurons, caveolin 1 (CAV1) and caveolin 2 (CAV2) are expressed together in a hetero-oligomeric complex (de Almeida, 2017) within membrane lipid rafts (MLRs) on the cell surface and have a key role in organization of intercellular signaling (Sawada et al., 2019; Schmick and Bastiaens, 2014). This evidence concerns the gene CAV2 and amyotrophic lateral sclerosis.