Here, we demonstrate that YAP/TAZ inhibit reparative phenotype by repressing expression of reparative genes such as Arg1. Expression of reparative genes such as Arg1, Ym1, Egr2, and Cd206 are increased in YAP/TAZ-deficient BMDMs stimulated with IL4/IL13, as well as in YAP/TAZ-deficient macrophages from the hearts at day 7 post-MI. The gene discussed is EGR2; the disease is myocardial infarction.