VEGFA and myocardial infarction: In contrast, reparative macrophages, responsible for preserving the structural integrity of the injured ventricle by promoting cardiac repair through myofibroblasts induction, collagen deposition, and neovascularization, dominate the heart at day 5 to 7 post-MI and secrete high level of anti-inflammatory cytokines and angiogenic factors such as IL-10, vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF2), and transforming growth factor beta (TGFβ) [3,11,14–18].