SIX3 and lung cancer: We found that mRNA expression of SMURF2 and TRIM27 was increased and that of SIX3 decreased in lung cancer tissues compared with those found in adjacent normal lung tissues (Figure 1B); however, correlations between SIX3 mRNA level and SMURF2 or TRIM27 mRNA level were not significant (Figure 1C; median value used as cut-off).