Similarly, SMURF2-dependent ubiquitin degradation of TGFβ receptors contributes to the inhibition of lung cancer cell proliferation, migration, and invasion [33], whereas low NEDD4L expression correlates with poor outcome in patients with lung cancer and promotes TGFβ-induced epithelial-to-mesenchymal transition [34]. Here, SMURF2 is linked to lung carcinoma.