Similarly, the amount of protein of SMURF2 and TRIM27 was also increased and that of SIX3 was decreased in lung cancer tissues compared with adjacent normal lung tissues (Figure 1D), although we found that there was a significant correlation between the protein level of SIX3 and TRIM27, but not of SMURF2 (Figure 1E). Here, SMURF2 is linked to lung cancer.