ESR1 and breast lobular carcinoma: Classic lobular carcinomas are usually ER‐positive/HER2‐negative tumors driven by CDH1 alterations and PIK3CA mutations [36], whereas secretory carcinoma is a low‐grade triple‐negative breast cancer with a recurrent ETV6‐NTRK3 fusion gene and is not driven by PI3K pathway alterations [37].