CD274 and non-small cell lung carcinoma: For example, recommended 1L therapies for patients with sensitizing EGFR mutations include osimertinib (preferred, category 1), erlotinib (alone or with ramucirumab or bevacizumab), afatinib, gefitinib, and dacomitinib.(NCCN Guidelines for Non-Small Cell Lung Cancer 6.2020) In addition to conventional targeted therapies, immuno-oncology (IO) agents are now recommended for patients with PD-L1 expression and favorable performance status (PS).