Intriguingly, circulating cardiovascular hormones, such as the N terminal pro peptide of the brain natriuretic peptide (NT-proBNP), have been shown to be related to cancer disease progression and severity, suggesting the presence of subclinical functional and morphological heart damage, providing hints for HF therapy in cancer patients beyond the focus of prevention of anticancer drug–induced cardiotoxicity [59]. This evidence concerns the gene NPPB and hydrops fetalis.