Lastly, a mouse model for Arid1b and Smarcb1 deficits (Coffin-Siris Syndrome) indeed mirror the human phenotype, as Arid1b+/− and Smarcb1+/inv NesCre+/− mice also have a significantly reduced corpus callosum thickness [277, 282]. The gene discussed is SMARCB1; the disease is Coffin-Siris syndrome.