CHD8 and Anxiety: In addition to altered myelination, conditional knockout of Chd8 in OPCs (Olig1-Cre;Chd8fl/fl) has been shown to slow down action potential propagation as a result of impaired myelination, leading to deficits including increased social interaction and anxiety-like behaviour as similar to Chd8 heterozygous mutant mice [244] and behavioural phenotypes found in patients.