The amino terminal fragment of the prohormone brain-type natriuretic peptide (NT-proBNP) test has been used in adults with cardiac failure.29 Evidence has found that the NT-proBNP test is useful in infants who require neonatal intensive care, children with pulmonary hypertension and cardiomyopathies, and children with various types of CHD.30,31,32,33,34,35,36,37 Small studies on the use of natriuretic peptides in children have been published.38,39,40. This evidence concerns the gene NPPB and pulmonary hypertension.