MAPT and Alzheimer disease: These same brain regions are also vulnerable to AD proteinopathies: intracellular neurofibrillary tangles of tau37,38 and extracellular amyloid-β peptide proteins.39,40,41,42,43,44 There is increasing evidence of an association between anosognosia in the predementia stages with amyloid and tau,6,9,19,20 indicating a possible connection among AD pathological deposits, structural brain damage, and functionality of the large-scale brain systems.