When trans-acting SNVs were included in the genetic instruments for MCP1 and HGF, there were positive genetic associations with ischemic stroke, but the genetic association for MCP1 was entirely driven by 38 trans–protein quantitative trait loci (pQTLs) and, for HGF, by the 2 trans-pQTLs (eTable 8 and eFigure 10 in the Supplement). The gene discussed is CCL2; the disease is ischemic stroke.