TNF and Sepsis: For instance, Chen et al. demonstrated that, in lipopolysaccharide-tolerant THP-1 cells of a sepsis model, resveratrol, a potential SIRT1 activator, stimulates SIRT1 activity and impedes the transcription of tumor necrosis factor-α (TNF-α) via the deacetylation of H4K16, which decrease inflammation (12).