In the present study, we found that: 1) SIRT1 was reduced in sepsis patients compared with HCs, and the ROC curve showed that SIRT1 distinguished sepsis patients from HCs; 2) SIRT1 negatively correlated with Scr, WBC, CRP, SOFA score, and APACHE II score, whereas it positively correlated with albumin in sepsis patients; and 3) SIRT1 negatively correlated with 28-day mortality, and ROC curve showed that SIRT1 predicted 28-day mortality in sepsis patients. Here, SIRT1 is linked to Sepsis.