IL18 and Sepsis: Khader et al. (13) showed that SRT1720, a SIRT1 activator, alleviates multiple organ injury via attenuating proinflammatory cytokines (e.g., interleukin (IL)-1β and IL-6) and reducing the activation of inflammasome (e.g., nucleotide oligomerization domain-like receptor protein 3 and IL-18), in a mouse model of sepsis.