Finally, receiver operating characteristic (ROC) curves were generated to determine the diagnostic value of the cytokines.<h4>Results</h4>IL-1β and TGF-β levels were higher in the serum of BE patients than those in non-BE patients, and the expression of either IL-1β or TGF-β showed a strong positive correlation with the serum expression of bilirubin in BE patients. The gene discussed is TGFB1; the disease is Barrett esophagus.