In contrast to the tumor suppressor p53 with its extensive set of target genes controlling the cell cycle and apoptosis (Fischer, 2017; Sammons et al., 2020), its phylogenetically ancient sibling p63 (ΔNp63) governs epidermis development (Mills et al., 1999; Yang et al., 1999) and is an oncogenic driver of squamous cell carcinoma (SCC) (Cancer Genome Atlas Research Network et al., 2018; Gatti et al., 2019) that is overexpressed or amplified in SCCs, which depend on its expression (Ramsey et al., 2013). This evidence concerns the gene TP63 and squamous cell carcinoma.