Although we did not identify COVID-19 infection in any of our patients with innate immune defects, this observation may also indicate future follow-up on patients with defects in TLR and IFN pathways are required to understand the genetic predisposition and pathogenesis of COVID-19 correctly, as 23 patients with disease-causing variants and life-threatening COVID-19 have been reported recently [39]. Here, IFNA1 is linked to COVID-19.