Even so, it is important to understand that the sets of genes that are induced or repressed by this transcription factor are cell type-specific; for example, Prox1 is found to promote the shift of colorectal cancer from benign to highly dysplastic, despite the lack of overlap between Prox1-induced genes in LECs vs. these colorectal cancer cells (48). Here, PROX1 is linked to colorectal cancer.