There are three canonical Ras genes (H-Ras, N-Ras, or K-Ras), which vary in distribution and frequency across different organs/cancers (105); K-Ras mutations are present in a majority of pancreatic ductal cancers but uncommon in bladder tumors, where H-Ras mutations are likely detected (97). Here, HRAS is linked to urinary bladder neoplasm.