Further studies revealed the importance of Ras signaling during development, with a collection of unique mutations leading to disorders commonly referred to as “RASopathies.” RASopathies are a class of developmental disorders caused via germline mutations in important regulators of the Ras-ERK pathway (106), though PI3K-AKT signaling participates in this pathophysiology as well (107). The gene discussed is PIK3CA; the disease is RASopathy.