KEAP1 and Friedreich ataxia: In FRDA patient fibroblasts, Nrf2 is significantly upregulated at both the mRNA and protein levels by treatment with sulforaphane (Keap1 oxidant), DMF, NAC (L-cysteine pro-drug), EPI-743 (mitochondrial metabolism promotion and glutathione synthesis), idebenone, and omaveloxolone (Petrillo et al., 2019).