Recently, Sanchez et al. (10) confirmed that dietary fiber-derived SCFAs reduced the autoantibody response (ANA, anti-dsDNA, anti-histone, anti-RNP/Sm, and anti-RNA IgG1 and IgG2a) and autoimmunity in lupus-prone mice. The gene discussed is BTG3; the disease is systemic lupus erythematosus.