TNFRSF10A and systemic lupus erythematosus: HLA-DR haplotypes are known to confer risk for a variety of immune-mediated disorders (Figure 1): HLA DR3 is associated to Graves disease, myasthenia gravis, systemic lupus erythematosus (SLE), Hashimoto's thyroiditis, and type 1 diabetes, the last two also associated to DR4.