RB1 and ovarian neoplasm: Other authors reported significantly lower pRb levels in low malignant potential ovarian tumors (LMP) than in carcinomas and in this latter group, a reduction of pRb expression with increasing grade, advancing stage and bulk residual disease; in their study, a low pRb to Ki-67 ratio appeared as an indicator of poor survival in uni- and multivariate analysis, along with the histologic type and FIGO stage (26).