In addition, transcriptional factor hypoxia-inducible factor 1 subunit alpha (HIF1A/HIF1α)-mediated BNIP3L upregulation is required for hypoxia-induced mitophagy (Sowter et al., 2001), indicating a potential role of BNIP3L-mediated mitophagy in hypoxic tumor microenvironments (TMEs). This evidence concerns the gene HIF1A and neoplasm.