Although zebrafish lacking Nipsnap1 show a decrease in mitochondria in the brain, which is coupled with the production of ROS, the loss of dopaminergic neurons, and a strong decrease in movement (Princely Abudu et al., 2019), the impact of NIPSNAP1 or NIPSNAP2-mediated mitophagy in neurodegenerative disease in mice or humans remains unknown. The gene discussed is NIPSNAP1; the disease is neurodegenerative disease.