BNIP3L and neoplasm: For example, the loss of BNIP3L in the KPC (LSL-KrasG12D; Tp53R172H; Pdx1-Cre) model of pancreatic ductal adenocarcinoma (PDAC) delays tumor occurrence, which is associated with reduced mitophagy and attenuated progression from the pancreatic intraepithelial neoplasia stage to PDAC (Humpton et al., 2019).