For example, C18-ceramide synthesized by ceramide synthase 1 (CERS1) induces mitophagy and tumor suppression in head and neck squamous cell carcinoma cells (Sentelle et al., 2012) and acute myeloid leukemia cells (Dany et al., 2016) in vitro and in vivo. Here, CERS1 is linked to acute myeloid leukemia.