HMGB1 and pancreatic neoplasm: Mechanistically, PINK1- and PRKN-mediated autophagy degradation of mitochondrial iron importers [e.g., solute carrier family 25 member 37 (SLC25A37) and solute carrier family 25 member 28 (SLC25A28)] suppresses pancreatic tumors by attenuating mitochondrial iron accumulation, inflammasome activation, high-mobility group box 1 (HMGB1) release, and subsequent immune checkpoint expression (Li et al., 2018).