The combination of PSA derivatives (AUC=0.88 for PCa, and AUC=0.90 for CSPCa) or mpMRI derivatives (AUC=0.84 for PCa, and AUC=0.86 for CSPCa) outperformed single derivatives in diagnostic of PCa and CSPCa (all p<0.05). This evidence concerns the gene KLK3 and posterior cortical atrophy.