Notch1 expression was evaluated in bone marrow of MM patients and healthy donors using RT-qPCR, which demonstrated an appreciably higher Notch1 expression in the bone marrow of MM patients than in the bone marrow of healthy donors (p < 0.05, Figure 5A), which was inversely correlated with NEDD4 expression (Figure 5B). Here, NEDD4 is linked to Miyoshi myopathy.