NQO1 and head and neck squamous cell carcinoma: Recognizing the importance of NAD(P)H availability to sustain the NQO1-dependent activity of β-lap, we have started to investigate the metabolic contribution to intracellular NAD(P)H first by computational flux balance analysis taking advantage of HNSCC data available in online repositories (e.g., TCGA, Human Protein Atlas), and multi-omics data collected for a matched model of response to radiation (radiation sensitive SCC-61 and radiation resistant rSCC-61) developed by our group (17–21).