There is a need for new molecular approaches to treat radiation resistant HNSCC tumors using combination therapies, and indeed, current efforts to enhance the efficacy of radiation therapy in HNSCC include combination treatment with targeted therapies (e.g., against Epidermal Growth Factor Receptor, EGFR), and immunomodulators, which are increasingly investigated in clinical studies (3). This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.