As expected based on the results of the cell culture studies, the scRNA rSCC-61 tumors were more sensitive to β-lap than to ionizing radiation, and the combined ionizing radiation and β-lap treatment (2 Gy followed by β-lap 20 mg/kg body weight) resulted in an almost complete suppression of tumor growth irrespective of MTHFD2 status. This evidence concerns the gene MTHFD2 and neoplasm.