This study recorded that the incidence of MI in the TNF-α inhibitor group, oral/phototherapy group, and topical therapy group was 3.05, 3.85, and 6.73 per 1000 patient-years, respectively (p < 0.001) after a median follow-up of 4.3 years [41]. The gene discussed is TNF; the disease is myocardial infarction.