EFTUD2 and Cowden syndrome 1: Very recently, new craniofacial phenotypes, i.e., metopic craniosynostosis (CS) and cleft lip and palate, were reported in two individuals carrying heterozygous variants–c.2466+1G>A in intron 24 and c.2333C>A in exon 23 of EFTUD2. These cases were initially suspected of having an alternative craniofacial syndrome and were eventually diagnosed with MFDGA (Lacour et al., 2019).