However, miR-149-5p overexpression inhibits vascular smooth muscle cell proliferation, invasion, and migration by interacting with HDAC4 (Zhang et al., 2019), and it can function as a negative regulator of melanoma cell proliferation and cell survival and promote apoptosis by targeting LRIG2 (Chen et al., 2017), suggesting that miR-149-5p functions as a therapeutic molecule against melanoma. Here, LRIG2 is linked to melanoma.