MBL2 and cryohydrocytosis: The plasma level of MBL was significantly lower in CHS patients compared to controls [median (IQR): 293.10 (158.98 and 489.20) ng/ml vs. 482.64 (169.12 and 745.84) ng/ml, p = 0.008], whereas CHC patients had significantly higher levels of plasma MBL than that of controls [median (IQR): 681.32 (506.88 and 978.34) ng/ml vs. 482.64 (169.12 and 745.84) ng/ml, p = 0.001] (Figure 1A).