However, compared to CHC patients, CHS patients had decreased levels of certain cytokines, such as IFN-γ, IFN-α, IL-1α, IL-10, IL-13, IL-4, IL-6, and TNF-α, suggesting that these cytokines may play a part in the development of HCV chronicity. The gene discussed is IL10; the disease is cryohydrocytosis.