Noteworthy, GrB (18, 21, 77), as some other granzymes (78–80), has been recently proposed as promoters of EMT, an important process linked the stimulation of the three following events: 1) tissue and organ formation during embryogenesis; 2) tissue and organ physiologic repair and pathologic fibrosis; 3) tumor cell invasion and metastasis (81). The gene discussed is GZMB; the disease is neoplasm.