(25) showed GrB contribution to acute lung injury in pneumovirus-infected mice; GrB deficiency in pneumovirus-infected mice significantly delayed clinical response to fatal pneumovirus infection and this effect was associated with delayed neutrophil recruitment, decreased caspase-3 activation and reduced lung permeability, suggesting a role for GrB in acute disease progression due to alveolar injury. This evidence concerns the gene GZMB and Pneumovirus Infections.