This indicates the importance of E-selectin (ligand for, e.g., PSGL-1) and L-selectin (ligand for, e.g., GlyCAM-1, CD34, etc.)for myeloid cell recruitment in cancer (62).The integrin VLA-4 has been shown to regulate recruitment of classical monocytes to tumors promoting angiogenesis (146). This evidence concerns the gene SELE and cancer.