ANGPT2 and neoplasm: In addition to the effects of VEGF blockade on the tumor vasculature, single targeting of VEGF or in combination with Ang2 blockade converted the immunosuppressive environment into an immune stimulatory environment, evidenced by increased detection of M1 macrophages and increased CD8+ T cells infiltration in GL261 glioblastoma tumors (35), or in a model of MCaP0008 breast cancer (32).