Perhaps in pancreatic and hepatocellular cancer LFA-1 mediated CD8+ T cell extravasation via its other ligands including ICAM-2, ICAM-3, ICAM-4, ICAM-5, and JAM-A (99), which might play an important role to establish firm adhesion to cancer endothelium Together this supports a model for CD8+ T cell transmigration across cancer endothelium that occurs predominantly through the CD8+ T cell attracting chemokines CCL2, CXCL9, and CXCL10, as well as via CD8+ T cell integrins, LFA-1 and VLA-4, and endothelial E-selectin, ICAM-1 and VCAM-1. The gene discussed is ICAM3; the disease is cancer.