The co-expression of BAFF/TNFSF13B and APRIL/TNFSF13 in the plaque lymphocytes and macrophages up-regulate FURIN, the primary Proprotein convertase subtilisin/Kexin (PCSK), which inactivates lipases and regulates inflammation in atherosclerosis (19). This evidence concerns the gene TNFSF13 and atherosclerosis.