EDA-containing FN fragments are widely recognized as ECM-DAMPs, and are upregulated in several inflammatory diseases (myocardial infarction, cardiac fibrosis, stroke, cerebral ischemia, airway fibrosis, dermal fibrosis, liver fibrosis), where they activate both immune and non-immune cells prolonging inflammation and fibrosis (271, 274, 409–417). Here, FN1 is linked to Hepatic fibrosis.