- Upregulated in liver fibrosis in a TGF-β1-dependent manner (178)- Involved in macrophage infiltration and liver fibrosis development (111)- Increased serum level correlates with higher levels of TGF-β1 and TGF-β2 in patients with acute and chronic hepatitis (111)- Implicated in NAFLD progression to NASH (179,180). The gene discussed is TGFB2; the disease is chronic hepatitis.