Direct Ligand: Immune cell interactions- Upregulated in various inflammatory diseases (170,171,172, 173, 174),- In asthma, it correlates with Th2-high phenotype with high expression of IL-13 and IL-5 (175,176)- Amplifies Th2 immune response in allergic skin inflammation and facilitates adhesion of eosinophils to the ECM (177). This evidence concerns the gene IL5 and asthma.