Although TSP-1 is minimally expressed in the normal liver, hepatocytes and HSCs show deposition of large amounts of TSP-1 in patients with congenital liver fibrosis (291), and TSP-1 is upregulated in liver samples from patients with alcohol cirrhosis and NASH-related cirrhosis (140). Here, THBS1 is linked to metabolic dysfunction-associated steatohepatitis.