Some ECM-DAMPs with clear pro-inflammatory activities (biglycan fragments, EDPs, LAM-P1) were found to correlate with severity of fibrosis and inflammation in ALD and NAFLD/NASH, while others (LMW-HA, EDA-FN fragments, biglycan fragments, HS fragments) have not been identified or studied in CLDs. Here, FN1 is linked to metabolic dysfunction-associated steatotic liver disease.