In the liver, tenascin-C knockout mice with liver fibrosis induced by concanavalin A showed protection against collagen deposition and inflammatory cell infiltration, reduced IFN-γ, TNF, IL-4, and TGF-β1 production, and a lower number of activated HSCs in respect to wild type animals (239). The gene discussed is TGFB1; the disease is Hepatic fibrosis.