It has been reported that P2X7R may retain specific migration and phagocytic properties, as it is essential for CX3CL1 chemoattraction (Fernandes et al., 2016), promote migration toward amyloid senile plaques upon activation while inhibiting microglial phagocytic capacity (Martínez-Frailes et al., 2019), and appears to have a permissive role for NF-κB activation, NLRP3 inflammasome formation and mitochondria toxicity in the microglia (Chiozzi et al., 2019). Here, CX3CL1 is linked to amyloidosis.