Genetically deficient animals for the receptor displayed a lower susceptibility to the psychotomimetic effects of the dissociative anesthetic, while the overexpression of the purinergic receptor produced a typically positive symptom response within a sub-optimal PCP dose for psychosis-like activity (Paasonen et al., 2017) and exacerbated stereotypy with an acute psychotomimetic 10 mg/kg PCP dose. The gene discussed is P2RX7; the disease is psychotic disorder.