Fourteen common genes including BDNF, GRM5, ADK, CREB1, GNB1, IL10, ADA, ENTPD1, WDTC1, NT5E, GDNF, P2RY2, SLC29A1, and RPIA were identified as potential targets of ADORA2A in epilepsy. Here, RPIA is linked to epilepsy.