Fourteen common genes including BDNF, GRM5, ADK, CREB1, GNB1, IL10, ADA, ENTPD1, WDTC1, NT5E, GDNF, P2RY2, SLC29A1, and RPIA were identified as potential targets of ADORA2A in epilepsy. The gene discussed is GNB1; the disease is epilepsy.