Fourteen common genes including BDNF, GRM5, ADK, CREB1, GNB1, IL10, ADA, ENTPD1, WDTC1, NT5E, GDNF, P2RY2, SLC29A1, and RPIA were identified as potential targets of ADORA2A in epilepsy. This evidence concerns the gene CREB1 and epilepsy.