EGFR and cancer: The regulation of certain receptors that are known to affect cancer and metastasis (i.e., EGFR and transforming growth factor β receptor (TGFβR)) by clathrin- and non-clathrin-mediated internalisation pathways preferentially targets the receptors to different fates (i.e., recycling or degradation).19,20 Different fates of receptors determine the net signalling output in a cell and affect cancer progression.