WDFY2 and oral cavity squamous cell carcinoma: In oral squamous cell carcinoma (SCC), increased αVβ6 integrin expression leads to the activation of MMP-3 and promotes oral SCC cell proliferation and metastasis in vivo.57 MMP-14 (membrane type 1 metalloprotease MT1-MMP), along with integrin αVβ3 co-localised to the protruding ends of invadopodia, and its high local concentration on the cell membrane promoted metastasis.58 Interestingly, WDFY2 (a cytosolic protein) controls the recycling of MT1-MMP to the membrane, and loss of WDFY2 leads to enhanced secretion of MT1-MMP leading to active invasion of cells.59