This leads to activation of a positive feedback loop involving enhanced epidermal growth factor receptor (EGFR)-dependent Akt/GSK-3β (glycogen synthase kinase 3β) phosphorylation, resulting in increased cell migration and metastasis.17 Dynamin 2 is crucial for the endocytosis of several proteins known to be involved in cancer motility and invasiveness (e.g., β-1 integrin and focal adhesion kinase). This evidence concerns the gene EGFR and cancer.