For example, OX40 is upregulated on activated CD4+ and CD8+ T cells, and an agonistic antibody of OX40 synergises with an inhibitor of transforming growth factor (TGF)-β to reduce the primary tumour growth of 4T1 mammary cells as well as spontaneous lung metastasis.38 The gene discussed is TGFB1; the disease is neoplasm.