Inhibition of CXCR2 in models of spontaneous metastasis—such as the KrasG12D;Trp53R172H;Pdx1-Cre (KPC) pancreatic cancer model or the Villin-CreER;KrasG12D;Trp53F/F;Rosa26N1cd/+ (KPN) colon cancer model—reduces the occurrence of secondary tumours in the liver without affecting survival.92,93 In the context of liver metastasis as well as lung metastasis,75 neutrophils suppress CD8+ T-cell responses to help disseminated cancer cells evade anti-tumour immunity, suggesting that combining neutrophil targeting with T-cell-based immunotherapy might be better than either approach alone. Here, PDX1 is linked to neoplasm.