Conversely, the ileal immune tonus was affected by colonic carcinogenesis as indicated by the fact that the since growth of heterotopic (s.c. MC38) or orthotopic (EMT-induced Zeb2-transgenic) colon cancers induced this upregulation of ileal immune gene products (Fig. 2C, D). Here, ZEB2 is linked to malignant colon neoplasm.