To demonstrate the role of miR-29b-2 and miR-338 in the FOXO3a-mediated repression of VEGF-A/NRP1 and breast cancer metastasis, we determined whether the FOXO3a-mediated repression of VEGF-A/NRP1 can be reversed by knockdown of miR-29b-2 and miR-338. The gene discussed is FOXO3; the disease is breast cancer.