Moreover, using human pancreatic cancer cell lines and orthotopic pancreatic cancer models, NK cells were found to be cytotoxic to cancer stem cells (CSCs) through the NKG2D-dependent recognition of the CSCs markers such as CD133 and CD24, highlighting the promising role of NK cells in the control of tumor recurrence and metastasis [23]. The gene discussed is PROM1; the disease is familial pancreatic carcinoma.