Similarly, in MC38 (murine primary colon carcinoma cell line)-based liver metastasis of CRC mice model, Nlrp3 inflammasome can increase the IL-18 secretion and promote the maturation of hepatic NK cells with increasing FasL expression, the Fas/FasL interaction can exert cytotoxicity towards tumor cells [26]. The gene discussed is FASLG; the disease is colon carcinoma.