FCGR3A and neoplasm: From the antibody-dependent cell-mediated cytotoxicity (ADCC) of NK cell function mechanism, specially designed bi- and tri-specific killer engagers (BiKEs and TriKEs), the small molecules linking a single-chain Fv against CD16 that is expressed on the NK cell with one (BiKE) or two (TriKE) tumor-associated antigens, were developed to improve the formation of immunological synapses between NK cells and tumor cells.