As expected, pDCs from healthy controls, At-Risk individuals, and SLE patients strongly expressed TLR9 and TLR7; however, no differences were found among the different groups regardless of IFN activity, in line with the intracellular expression of TLR9 and TLR7 at protein level (Fig. 2g, h). Here, TLR7 is linked to systemic lupus erythematosus.