IFNA2 and systemic lupus erythematosus: We next evaluated whether there was any association between IFN-α production by pDCs and overall blood type I IFN activity as measured by IFN score A. We found no association between the levels of TLR-mediated IFN-α production and the level of IFN score A in patients with SLE and pSS as well as At-Risk individuals (Supplementary Fig. 3a–d).