We found that IFN score A was associated with mucocutaneous disease activity (fold difference 2.24 (95% CI 1.16–4.34); P = 0.017), but not with the musculoskeletal disease (fold difference 0.97 (95% CI 0.44–2.09); P = 0.927). This evidence concerns the gene IFNA1 and glycogen storage disease VI.