Autism risk genes, ARID1B, SHANK3 and NRXN2 were specially of interst, using a dual-luciferase assay we confirmed the direct targeting of MRE of SHANK3 by miR-873 albeit, WT and Mut miR-873 mimics similarly dysregulate Renilla luciferase. The gene discussed is ARID1B; the disease is autism.