A recent study from our group used systems biology tools to address differences between mild versus severe COVID-19 patients [34], where we found increased levels of proinflammatory cytokines such as IL6, MCP-1, CXCL10 in the blood of COVID-19 patients, as well as upregulation of LIGHT (TNFSF14), EN-RAGE, and oncostatin-M, which correlated strongly with the severity of disease. The gene discussed is S100A12; the disease is COVID-19.