To further investigate the association of CLU with tau accumulation, we used a well-established mouse model of tauopathy [3] in which adeno-associated virus expressing human tau protein bearing the P301L mutation (AAV-TauP301L) or green fluorescent protein as control (AAV-GFP) was delivered to CLU wild-type (WT) and CLU knock-out (KO) animals by intracerebroventricular injections at postnatal day 0. Here, MAPT is linked to tauopathy.